The prognostic and predictive value of osteopontin in colon adenocarcinoma

Aim: The identification of cellular pathways in colorectal tumor biology is essential for early diagnosis, treatment, and post-treatment follow-up. Osteopontin an extracellular matrix protein that has regulatory physiological functions roles apoptosis, proliferation, adhesion, invasion, metastasis. In this study, we aimed to determine the prognostic predictive value osteopontin colon adenocarcinoma. Our study investigated whether expression had any or use adenocarcinoma also if there were differences between adenoma. Methods: Fifty these colonic specimens adenocarcinoma, 16 adenomatous polyps, 10 nontumoral tissue served as a control group. We used two-tiered evaluation system examined both staining intensity percentage staining. Results: scores tumors with vascular invasion significantly higher than those without (p=0.001). addition, tumoral tissues’ score polyps (p=0.001). Conclusion: If future studies support our results, suggest may be important biomarker predicting detecting could useful tumor-adenomatous polyp differentiation. Therefore, can provide helpful information diagnosis prognosis